The synthesis method of 96% Prochloraz is mainly based on the step-by-step construction of chemical reactions. The following are several common synthesis methods, each of which is described in detail:
1. Traditional dibromoethane method
Traditionally, the synthesis of 96% Prochloraz is prepared from 2,4,6-trichlorophenol through a series of chemical reactions. First, 2,4,6-trichlorophenol and 1,2-dibromoethane undergo a substitution reaction under alkaline conditions to generate 2-(2,4,6-trichlorophenoxy)ethyl bromide. Subsequently, the intermediate reacts with propylamine to generate N-(2,4,6-trichlorophenoxyethyl)propylamine. Next, the amine compound undergoes an acyl chloride reaction and reacts with phosgene to generate N-(2,4,6-trichlorophenoxyethyl)propylcarbamoyl chloride. Finally, the acyl chloride is condensed with imidazole under alkaline conditions to obtain 96% Prochloraz. This method has many steps, but the raw materials are relatively easy to obtain, and it is the main method for the early synthesis of 96% Prochloraz.
2. Improved Synthesis Route
With the development of chemical synthesis technology, researchers have optimized and improved the synthesis route of 96% Prochloraz. One improved method is to use 2,4,6-trichlorophenol and dichloroethane as etherification raw materials to directly generate N-(2,4,6-trichlorophenoxyethyl) chloride through etherification reaction. This step simplifies the two-step reaction of bromination and amination in the traditional method and improves the synthesis efficiency. Subsequently, the chlorinated product reacts with propylamine to generate the corresponding amine compound, which is then subjected to acyl chlorination and condensation reactions to finally obtain 96% Prochloraz. This improved synthesis route is simpler in operation and has lower costs.
3. Other Synthesis Methods
In addition to the above two main methods, some other synthesis methods have been reported. For example, by reacting the intermediate product generated by the reaction of imidazole with phosgene with 2,4,6-trichlorophenol and its derivatives, 96% Prochloraz can also be obtained by adjusting the reaction conditions and the ratio of the reactants. These methods may differ in synthesis steps and reaction conditions, but all aim to improve synthesis efficiency and product quality.
In summary, there are many methods for the synthesis of 96% Prochloraz, among which the traditional dibromoethane method and the improved synthesis route are the more common and mature methods. With the continuous development of chemical synthesis technology, more efficient and environmentally friendly synthesis methods may emerge in the future.
